Reverse-engineering B-Arrestin Bias in the d-Opioid Receptor
Tomasz Maciej Stępniewski, Manel Zeghal, Istvan Szabo, Maria Martí-Solano, Ismael Rodríguez‐Espigares, Elizaveta Korchevaya, Mariona Torrens-Fontanals, Gianni De Fabritiis, Slawomir Filipek, Patrick M. Giguère, Jana Selent
The paper uses molecular dynamics simulations to study signaling bias in the delta-opioid receptor, identifying structural determinants of beta-arrestin recruitment and demonstrating how mutations can reshape signaling profiles.
bioRxiv · Nov 27, 2025 · PreprintBioinformatics