Patrick M. Giguère

Reverse-engineering B-Arrestin Bias in the d-Opioid Receptor

The paper uses molecular dynamics simulations to study signaling bias in the delta-opioid receptor, identifying structural determinants of beta-arrestin recruitment and demonstrating how mutations can reshape signaling profiles.

Development of a multifunctional toolkit of intrabody-based biosensors recognizing the V5 peptide tag: highlighting applications with G protein-coupled receptors

The paper develops a toolkit of intrabody-based biosensors recognizing the V5 peptide tag and applies them to study G protein-coupled receptor signaling.

Identification of a High-frequency Intra-host SARS-CoV-2 spike Variant with Enhanced Cytopathic and Fusogenic Effect

The paper identifies a high-frequency intra-host SARS-CoV-2 spike variant with enhanced cytopathic and fusogenic effects through high-throughput sequencing analysis.

A Chemogenetic Platform for Spatio-temporal Control of β-arrestin Translocation and Signaling at G protein-Coupled Receptors

The paper introduces GA-PAIR, a chemogenetic platform that enables precise spatio-temporal control of β-arrestin signaling in GPCRs using ABA-induced protein interactions.