Analysis of single-cell RNA-seq data from ovarian cancer samples before and after chemotherapy links stress-related transcriptional profile withchemotherapy resistance
Kaiyang Zhang, Erdoğan Pekcan Erkan, Jun Dai, Noora Andersson, Katja Kaipio, Tarja Lamminen, Naziha Mansuri, Kaisa Huhtinen, Olli Carpén, Johanna Hynninen, Sakari Hietanen, Jaana Oikkonen, Antti Häkkinen, Sampsa Hautaniemi, Anna Vähärautio
The paper identifies a stress-related transcriptional profile in ovarian cancer linked to chemotherapy resistance and poor survival, suggesting MEK1/2 inhibitors as a potential treatment.
bioRxiv · Jun 6, 2020 · PreprintBioinformatics