Systems BiologyMetabolic EngineeringPeer-reviewed
Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells
Emanuel Gonçalves, Marco Sciacovelli, Ana S.H. Costa…·Julio Sáez-Rodríguez
The paper identifies phosphorylation sites in metabolic enzymes of FH-deficient cells using proteomics and computational modeling, showing PDHA1 inhibition due to increased phosphorylation.
32 citations