Christian Frezza

Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz

The paper introduces MetaProViz, an R package for metabolomics data analysis that integrates prior knowledge to generate mechanistic hypotheses, using kidney cancer data to demonstrate its capabilities.

Metabolic-secretory decoupling defines a disease-intrinsic state in rheumatoid arthritis monocytes

The paper identifies a stable metabolic-secretory defect in RA monocytes across activation states using multi-omics analysis, linking reduced glycosylation to disease mechanisms.

Cell state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer

The paper identifies metabolic differences between ASCL1-high and low SCLC cells, showing that ASCL1-high cells resist ferroptosis via BH4/BH2 antioxidants and are vulnerable to combined cysteine depletion and BH4/BH2 inhibition.

KRAS G12 mutant alleles differentially control glutamine metabolism via FOXO1

This study identifies how different KRAS G12 alleles alter glutamine metabolism and nitrogen recycling through FOXO1 regulation in colorectal cancer cells, revealing potential therapeutic targets.

Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

This study shows that autophagy regulator ATG5 protects cerebellar Purkinje cells by maintaining glycolytic activity, preventing neurodegeneration through regulation of glucose transporter 2.

Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

This study identifies increased cholesterol synthesis in PMS patient-derived neural progenitor cells as a driver of neurotoxicity, which can be mitigated by simvastatin.

Liver-like glycogen metabolism supports glycolysis in naked mole-rat heart during ischaemia

This study identifies a unique glycogen metabolism in naked mole-rat hearts during ischaemia, involving liver-like mechanisms and amylase activation for enhanced glycolytic flux and ATP maintenance.

Mitochondrial reverse electron transport in myeloid cells perpetuates neuroinflammation

The paper identifies mitochondrial reverse electron transport in myeloid cells as a driver of neuroinflammation and shows that blocking it protects the CNS in disease models.

A rare genetic disorder provides insights into mechanisms of early-onset neurodegeneration

This study investigates neurodegeneration in Xeroderma pigmentosum using stem cell-derived neurons, identifying endoplasmic reticulum stress and UPS dysfunction as key factors and developing an early detection assay.

Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses

COSMOS integrates multi-omics data with prior knowledge to generate mechanistic hypotheses about biological processes in renal cell carcinoma.

Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis

The paper shows yeast cells use temporal metabolic oscillations to coordinate protein synthesis with energy availability, storing resources and releasing them in bursts to maintain homeostasis.

Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells

This study shows neural stem cells transfer functional mitochondria via extracellular vesicles to restore mitochondrial function in target cells, improving disease outcomes in multiple sclerosis.

Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells

The paper identifies phosphorylation sites in metabolic enzymes of FH-deficient cells using proteomics and computational modeling, showing PDHA1 inhibition due to increased phosphorylation.