Marco Sciacovelli

The paper shows that tissue-wide metabolic buffering allows neural stem cells to maintain proliferation despite mitochondrial dysfunction, highlighting the role of tissue heterogeneity in resilience.

This study identifies how different KRAS G12 alleles alter glutamine metabolism and nitrogen recycling through FOXO1 regulation in colorectal cancer cells, revealing potential therapeutic targets.

COSMOS integrates multi-omics data with prior knowledge to generate mechanistic hypotheses about biological processes in renal cell carcinoma.

The paper identifies phosphorylation sites in metabolic enzymes of FH-deficient cells using proteomics and computational modeling, showing PDHA1 inhibition due to increased phosphorylation.