Austin T. Weigle

Deep mutational scanning reveals sequence to function constraints for SWEET family transporters

This study uses deep mutational scanning to analyze sequence-function relationships in the plant SWEET transporter AtSWEET13, identifying mutations that enhance transport function and revealing constraints in transmembrane helix 4.

Interplay between phosphorylation and oligomerization tunes the conformational ensemble of SWEET transporters

This study investigates how phosphorylation and oligomerization regulate SWEET transporter function through molecular dynamics simulations and Markov state models, revealing their impact on conformational states and extracellular gating.