Lingyun Xu

Substrate binding reorganizes the energetic landscape of Plasmodium falciparum hexose transporter PfHT1

This study shows how glucose binding reorganizes the conformational and energetic landscape of PfHT1, a malaria parasite transporter, using computational methods and experimental validation.

PanVariants: Best Practice for Pangenome-based Variant Calling Pipeline and Framework

PanVariants improves variant calling by integrating k-mer and mapping methods, reducing errors and outperforming existing tools for SNVs, indels, and SVs.

NeoAtlas and NeoBert: A Database and A Predictive Model for Canonical and Noncanonical Tumor Neoantigens

The paper curates noncanonical neoantigen-HLA pairs and develops predictive models, providing a public resource for neoantigen research and vaccine development.

Deep mutational scanning reveals sequence to function constraints for SWEET family transporters

This study uses deep mutational scanning to analyze sequence-function relationships in the plant SWEET transporter AtSWEET13, identifying mutations that enhance transport function and revealing constraints in transmembrane helix 4.