Nataša Josipović

The paper demonstrates that the 10x Genomics Gene Expression Flex protocol can profile mixed human and mouse cells in xenografts by using combined probe sets and a pipeline to remove cross-reactive signals.

This study uses a small molecule inhibitor to rapidly and synchronously induce senescence-like features in human cells, enabling analysis of its core regulatory program without paracrine effects.

This study identifies aging-associated increases in transcriptional elongation speed across multiple species and shows that reducing this speed extends lifespan.

The paper identifies circRAB3IP as a circRNA that modulates cell proliferation by altering gene expression and mRNA processing through interactions with SF3B1 in a paracrine manner.

The paper shows RNA polymerase II is necessary for spatial chromatin reorganization after mitosis, as demonstrated by Hi-C and in silico modeling.

This study shows human brain organoids can form bilateral optic vesicles with cellular diversity and functionality, including light-responsive photoreceptors and neuronal networks.

This study identifies HMGB1 as an RNA-binding protein that coordinates chromatin folding and RNA homeostasis in senescence through interactions with other RBPs and regulation of SASP-related transcripts.