Author

Rujin Wang

University of North Carolina at Chapel HillORCID 0000-0002-1632-446XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 3 Genetic & Genomic Medicine· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Assay:scRNA-seq· 3 Research Focus:variant calling· 2 Assay:whole-exome sequencing· 2 Approach:Bayesian inference· 1 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Yuchao JiangiD· 4 shared Adrián I. CamposiD· 1 shared Ajay NadigiD· 1 shared Alexander LachmanniD· 1 shared Amelia AverittiD· 1 shared Andrey ZiyatdinoviD· 1 shared Ann Marie WeidemaniD· 1 shared Anthony MarckettaiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBioinformatics

Yuchao JiangORCID

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6 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintJun 22, 2026

Rare loss-of-function variants in POLD1, PMS1 and FAN1 modify age at onset of motor symptoms in Huntington's disease

Sahar Gelfman, Rujin Wang, Adrián I. Campos…·Giovanni Coppola

1 citation

humanwhole-exome sequencing

Genetic & Genomic MedicineNature CommunicationsPeer-reviewedDec 23, 2025

Mapping rare protein-coding variants on multi-organ imaging traits

Yijun Fan, Jie Chen, Zirui Fan…·Bingxin Zhao

The paper identifies rare protein-coding variants associated with multi-organ MRI traits using exome-wide association analysis in the UK Biobank.

DOI 10.1038/s41467-025-67431-y

GenomicsStatistics in BiosciencesPeer-reviewedJan 8, 2025

Canopy2: tumor phylogeny inference by bulk DNA and single-cell RNA sequencing

Ann Marie Weideman, Rujin Wang, Joseph G. Ibrahim, Yuchao Jiang

Canopy2 infers tumor phylogeny using bulk DNA and single-cell RNA sequencing data, outperforming existing methods in reconstructing clonal trees.

7 citations

humanbulk RNA-seq

BioinformaticsPLoS GeneticsPeer-reviewedJun 16, 2022

EPIC: inferring relevant cell types for complex traits by integrating genome-wide association studies and single-cell RNA sequencing

Rujin Wang, Dan-Yu Lin, Yuchao Jiang

EPIC integrates GWAS summary statistics with scRNA-seq to identify cell types relevant to complex traits, outperforming existing methods in enrichment analysis.

20 citations

humanGWAS summary statistics

BioinformaticsCell SystemsPeer-reviewedMay 1, 2020

SCOPE: a normalization and copy number estimation method for single-cell DNA sequencing

Rujin Wang, Danyu Y. Lin, Yuchao Jiang

SCOPE improves copy number estimation in scDNA-seq data by normalizing biases and identifying subclonal structures in cancer cells.

99 citationstop 3%

BioinformaticsGenome biologyPeer-reviewedNov 26, 2018

CODEX2: full-spectrum copy number variation detection by high-throughput DNA sequencing

Yuchao Jiang, Rujin Wang, Eugene Urrutia…·Nancy Ruonan Zhang

CODEX2 improves CNV detection sensitivity and reduces false discoveries in whole-exome and targeted sequencing data.

77 citationstop 3%

whole-exome sequencingstatistical model