Author
University of North Carolina at Chapel HillORCID 0000-0002-0150-3115Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Paul Little, Si Liu, Vasyl Zhabotynsky, Yun Li, Danyu Y. Lin, Wei Sun
This paper introduces a statistical method to map cell type-specific eQTLs using bulk RNA-seq data, improving accuracy over existing methods by leveraging allele-specific expression.
bioRxiv · Mar 31, 2022 · PreprintGenomics
Pierrick Wainschtein, Deepti Jain, Zhili Zheng, TOPMed Anthropometry Working Group, Stella W. Aslibekyan, Diane M. Becker, Wenjian Bi, Jennifer A. Brody, Jenna C. Carlson, Adolfo Correa, Margaret Mengmeng Du, Lindsay Fernández‐Rhodes, Kendra Ferrier, Mariaelisa Graff, Xiuqing Guo, , Joshua C. Bis
The paper estimates heritability for height and BMI using whole-genome sequence data and finds that rare variants contribute significantly to the missing heritability.
Nature Genetics · Mar 1, 2022Peer-reviewedGenetics
Chong Jin, Mengjie Chen, Danyu Y. Lin, Wei Sun
The paper introduces CARseq, a framework for RNA-seq differential expression analysis that accounts for cell type composition, showing higher power and accuracy in identifying differentially expressed genes in schizophrenia and autism studies.
Nature Computational Science · Apr 15, 2021Peer-reviewedBioinformatics
Rujin Wang, Danyu Y. Lin, Yuchao Jiang
SCOPE improves copy number estimation in scDNA-seq data by normalizing biases and identifying subclonal structures in cancer cells.
Cell Systems · May 1, 2020Peer-reviewedBioinformatics