Jakub Jankowski

Y665F variant of mouse Stat5b protects against acute kidney injury through transcriptomic shifts in renal gene expression

The paper investigates the protective role of the Stat5bY665F mutation in acute kidney injury using mouse models and transcriptomic analyses.

Network medicine-based epistasis detection in complex diseases: ready for quantum computing

The paper introduces NeEDL, a network medicine-based method for detecting higher-order epistatic interactions in complex diseases, showing improved statistical significance and applicability across eight diseases.

Sexually dimorphic renal expression of Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b

The paper identifies a kidney-specific enhancer, E1, that regulates sexually dimorphic Klotho expression through HNF1b binding and shows its role in kidney injury responses.

circRNA-sponging: a pipeline for extensive analysis of circRNA expression and their role in miRNA sponging

The paper introduces circRNA-sponging, a pipeline to analyze circRNA expression and miRNA sponging, identifying two types of circRNAs based on binding site ratios.

TF-Prioritizer: a java pipeline to prioritize condition-specific transcription factors

TF-Prioritizer identifies condition-specific transcription factors using multi-modal genomic data and generates an interactive web report.

Interferon-regulated genetic programs and JAK/STAT pathway activate the intronic promoter of the short ACE2 isoform in renal proximal tubules

The paper identifies interferon-induced upregulation of the short ACE2 isoform (dACE2) in renal proximal tubule cells and links it to JAK/STAT pathway activation.