Chengyu Liu

Mutation of a single cysteine in CaMKIIδ protects the heart from ischemia-reperfusion Injury

This study shows that mutating Cys273 in CaMKIIδ prevents disulfide formation, protecting the heart from ischemia-reperfusion injury without affecting normal cardiac function.

Chromatin modifiers KMT2D, BAF, and p300 are required for de novo binding of transcription factors on enhancers

The paper shows that chromatin modifiers KMT2D, BAF, and p300 are required for de novo TF binding on enhancers, revealing cooperative interactions rather than a strict hierarchy.

ENDOTHELIAL PROX1 INDUCES BLOOD-BRAIN BARRIER DISRUPTION IN THE CENTRAL NERVOUS SYSTEM

This study shows that endothelial Prox1 overexpression disrupts the blood-brain barrier by downregulating BBB-associated genes and Wnt/β-catenin signaling during both embryonic and postnatal stages.

Optimal CXCR5 Expression during Tfh Maturation Involves the Bhlhe40-Pou2af1 Axis

This study identifies the Bhlhe40-Pou2af1 axis as a transcriptional regulator of CXCR5 expression in Tfh cells, independent of the Bcl6-Blimp1 pathway.

The DND1-NANOS3 complex shapes the primordial germ cell transcriptome via a heptanucleotide sequence in mRNA 3'UTRs

The paper identifies an RNA sequence motif recognized by the DND1-NANOS3 complex in germ cells and shows its role in regulating mRNA expression.

Overexpression of enhanced yellow fluorescent protein fused with Channelrhodopsin-2 causes contractile dysfunction in skeletal muscle

This study shows that overexpressing ChR2-EYFP in skeletal muscle causes contractile dysfunction, while ChR2-only mice show normal function, highlighting the need for alternative optogenetic models.

STAT5B SH2 variants disrupt mammary enhancers and the stability of genetic programs during pregnancy

The paper investigates how two STAT5B SH2 domain variants affect mammary tissue development and lactation by altering enhancer recognition and gene regulation in mice.

Sexually dimorphic renal expression of Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b

The paper identifies a kidney-specific enhancer, E1, that regulates sexually dimorphic Klotho expression through HNF1b binding and shows its role in kidney injury responses.

Mouse Homolog of Human IRF8G388S Mutation Provides Novel Insight into Osteoclastogenesis and Tooth Root Resorption

This study generates Irf8 knock-in mice modeling the human IRF8G388S mutation, showing increased osteoclast activity and tooth root resorption while sparing immune cell development.

A PARP inhibitor, rucaparib, improves cardiac dysfunction in ADP-ribose-acceptor hydrolase 3 (Arh3) deficiency

This study shows that ARH3 deficiency causes cardiac dysfunction and that rucaparib, a PARP inhibitor, improves cardiac contractility and reduces infarct size in ARH3-deficient mice.

Cell-specific and shared enhancers control a high-density multi-gene locus active in mammary and salivary glands

The paper identifies enhancers regulating a multigene locus active in mammary and salivary glands, showing how cell-specific and shared regulatory elements control gene expression.

A cytokine-responsive promoter is required for distal enhancer function mediating the hundreds-fold increase in milk protein gene expression during lactation

The paper identifies a cytokine-responsive promoter element critical for enhancing milk protein gene expression during lactation.

Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapse

This study identifies Auxilin mutations as a cause of Parkinson's disease by showing they impair clathrin-mediated trafficking at the Golgi and synapse, leading to neuropathological lesions.

Regulatory plasticity within a complex cytokine-sensing mammary enhancer during lactation

The paper investigates the structural and biological importance of transcription factor binding sites in a complex mammary enhancer during lactation, finding that deletion of canonical sites has limited impact but non-canonical sites are critical.

Robust generation of erythroid and multilineage hematopoietic progenitors from human iPSCs using a scalable monolayer culture system

This study develops a scalable monolayer culture system for generating erythroid and multilineage hematopoietic progenitors from human iPSCs, showing limited HSC engraftment potential.

Cytosine but not adenine base editor generates mutations in mice

The paper compares the fidelity of cytosine and adenine base editors in mice, finding BE4 generates more mutations than ABE.