Regulation of cell cycle by the novel GATA1/TAL1/Sphingomyelin Synthase 1 (SGMS1) transcriptional axis. Implications for anti-leukemic strategies.
Yasharah Raza, Sitapriya Moorthi, Gui-Qin Yu, Sam B Chiappone, Caterina Vacchi‐Suzzi, Chiara Luberto
This paper identifies SGMS1 as a novel target of the GATA1/TAL1 transcriptional complex and shows its role in G2/M cell cycle regulation, suggesting a potential therapeutic strategy for M6 AML.
bioRxiv · Jan 19, 2025 · PreprintCancer Biology