Chiara Luberto

Critical Evaluation of Sphingolipids Detection by MALDI-MSI

This study evaluates sphingolipid detection by MALDI-MSI, identifies optimal protocols, and reports artifacts from fragmentation in different ion modes.

Regulation of cell cycle by the novel GATA1/TAL1/Sphingomyelin Synthase 1 (SGMS1) transcriptional axis. Implications for anti-leukemic strategies.

This paper identifies SGMS1 as a novel target of the GATA1/TAL1 transcriptional complex and shows its role in G2/M cell cycle regulation, suggesting a potential therapeutic strategy for M6 AML.

Fenretinide targets GATA1 to induce cytotoxicity in GATA1 positive Acute Erythroid and Acute Megakaryoblastic Leukemic cells.

This paper identifies Fenretinide as a GATA1-targeting agent that induces cytotoxicity in M6 and M7 AML cells by causing GATA1 loss and overcomes chemotherapeutic resistance.