Author

Sam B Chiappone

Stony Brook University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Chiara LubertoiD· 2 shared Christopher J. ClarkeiD· 2 shared Fabiola Noelia VelazqueziD· 2 shared Victoria Franzi· 2 shared Yasharah RazaiD· 2 shared Yusuf Awni HannuniD· 2 shared Achraf A. ShamseddineiD· 1 shared Andrew E ResnickiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCancer Biology

Chiara LubertoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Neutral Sphingomyelinase-2 Restrains TAZ to Suppress Breast Tumor Growth

Andrew E Resnick, Victoria Franzi, Botheina Ghandour, Sam B Chiappone, Sébastien Lalanne, Monica Alexander, Deanna M Peperno, Jowana Obeid, Ishmam Pritam, Ian D Miranda, Nicolas Coant, Michael V. Airola, Mehdi Damaghi, Fabiola Noelia Velazquez, Yusuf Awni Hannun, Christopher J. Clarke

This study identifies nSMase2 as a metabolic tumor suppressor in breast cancer by restraining TAZ and inhibiting tumorigenesis.

bioRxiv · Jul 4, 2026 · PreprintCancer Biology

A Critical Role for Neutral Sphingomyelinase-2 in Doxorubicin-induced Cardiotoxicity

Samia Mohammed, Victoria Franzi, Yaping Jiang, Fabiola Noelia Velazquez, Monica E. Alexander, Folnetti A. Alvarez, Danielle Lambadis, Sam B Chiappone, Anne G. Ostermeyer‐Fay, Leiqing Zhang, Achraf A. Shamseddine, Daniel Canals, Ashley J. Snider, Richard Z. Lin, Yusuf Awni Hannun, Christopher J. Clarke

This study identifies nSMase2 as a critical mediator of Doxorubicin-induced cardiotoxicity and shows its loss protects against cardiac damage.

bioRxiv · Mar 20, 2025 · PreprintCell Biology

Regulation of cell cycle by the novel GATA1/TAL1/Sphingomyelin Synthase 1 (SGMS1) transcriptional axis. Implications for anti-leukemic strategies.

Yasharah Raza, Sitapriya Moorthi, Gui-Qin Yu, Sam B Chiappone, Caterina Vacchi‐Suzzi, Chiara Luberto

This paper identifies SGMS1 as a novel target of the GATA1/TAL1 transcriptional complex and shows its role in G2/M cell cycle regulation, suggesting a potential therapeutic strategy for M6 AML.

bioRxiv · Jan 19, 2025 · PreprintCancer Biology

Fenretinide targets GATA1 to induce cytotoxicity in GATA1 positive Acute Erythroid and Acute Megakaryoblastic Leukemic cells.

Yasharah Raza, Manal Elmasry, Guoying Yu, Sam B Chiappone, Suhu Liu, Chiara Luberto

This paper identifies Fenretinide as a GATA1-targeting agent that induces cytotoxicity in M6 and M7 AML cells by causing GATA1 loss and overcomes chemotherapeutic resistance.

bioRxiv · Jan 19, 2025 · PreprintCancer Biology