Synaptic architecture of a memory engram in the mouse hippocampus
Marco Uytiepo, Yongchuan Zhu, Eric A. Bushong, Katherine Chou, Filip S. Polli, Elise Zhao, Keun-young Kim A, Danielle Luu, Lyanne Chang, Dong Uk Yang, Tsz Ching Ma, Mingi Kim, Yuting Zhang, Grant Walton, Tom C. Quach, , Anton Maximov
The paper investigates the synaptic architecture of memory engrams in the mouse hippocampus, revealing that memory acquisition involves expansion of connectomes through multi-synaptic boutons without altering axonal terminals or dendritic spines.
Science · Mar 20, 2025Peer-reviewedNeuroscience