Filip S. Polli

The paper investigates the synaptic architecture of memory engrams in the mouse hippocampus, revealing that memory acquisition involves expansion of connectomes through multi-synaptic boutons without altering axonal terminals or dendritic spines.

The paper identifies phosphorylated pyruvate dehydrogenase (pPDH) as an in vivo marker for neuronal inhibition, correlating with reduced action potential firing and detectable across various inhibitory conditions.

This study shows Nr4a1 regulates synaptic organizer molecule transcription in inhibitory interneurons, affecting axonal wiring and transcriptional switches in mouse forebrain.