Eric A. Bushong

This study shows that blocking fibrin-induced microglia activation reduces neuronal hyperactivity and restores the neuroimmune interactome in Alzheimer's disease.

The paper maps the endomembrane system of cerebellar Purkinje neurons using electron microscopy, revealing cell-type-specific and subcellular structural organization of organelles.

The paper investigates the synaptic architecture of memory engrams in the mouse hippocampus, revealing that memory acquisition involves expansion of connectomes through multi-synaptic boutons without altering axonal terminals or dendritic spines.

This study investigates how mTOR inhibition reverses glioma-induced changes in excitatory neurons, showing effects on mRNA, dendritic spines, and neuronal activity.

The paper investigates whether perineuronal nets (PNNs) stabilize synaptic circuits and engram formation through high-resolution imaging and experimental approaches.

The paper tracks single HSPCs in zebrafish using light and electron microscopy to identify a new niche cell type and resolve their ultrastructural interactions.

The paper analyzes mitochondrial morphology in mouse cerebellum neurons using 3D TEM data to quantify structural features that influence metabolic output.

The paper systematically analyzes the morphology and morphometry of Drosophila olfactory receptor neurons using electron microscopy, revealing novel features and providing a dataset for future studies.

The paper investigates how a motor neuron dynamically switches roles across behaviors without changing its anatomical connections by analyzing circuit anatomy and activity patterns.

This study shows that Aβ-induced synaptic injury in hippocampal neurons is mediated by presynaptic APP expression, as demonstrated by orientation-specific LTP reduction and synaptic loss.

This study shows that class IIa HDACs 4 and 5 regulate early response gene expression during learning, affecting memory formation and synaptic function.

The paper demonstrates asymmetric ephaptic inhibition between olfactory receptor neurons in Drosophila, showing that the larger neuron in a pair dominates the interaction.

The paper combines serial electron microscopy with electrophysiology to confirm, challenge, and discover synapses in the leech ganglion, demonstrating the value of integrating connectomics with physiological studies.