Systems BiologybioRxivPreprint
Multivalent, asymmetric IL-2-Fc fusions provide optimally enhanced regulatory T cell selectivity
Brian T. Orcutt-Jahns, Peter C. Emmel, Eli M. Snyder…·Aaron S. Meyer
This paper systematically evaluates IL-2-Fc fusions to enhance Treg selectivity by exploring valency, orientation, and binding kinetics, identifying multivalency and asymmetry as key factors for improved specificity.
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