Brian T. Orcutt-Jahns

This study uses dynamic caging to link live-cell behavior with transcriptional responses across perturbations, revealing new insights into immune and inflammatory gene regulation.

This paper introduces CompBioBench, a benchmark for evaluating agentic systems in computational biology, showing strong performance across diverse tasks.

RISE, an adaptation of PARAFAC2, enables dimensionality reduction and analysis of single-cell RNA-seq data across experimental conditions by separating condition-specific effects from cell-to-cell variation.

This paper systematically evaluates IL-2-Fc fusions to enhance Treg selectivity by exploring valency, orientation, and binding kinetics, identifying multivalency and asymmetry as key factors for improved specificity.