Cancer BiologybioRxivPreprint
NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages drive chemoradiotherapy resistance in esophageal squamous cell carcinoma
Jiaying Deng, Zhenzhen Xun, Hu Chen…·Han Liang
This study identifies NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages as drivers of chemoradiotherapy resistance in ESCC through multi-omics analysis of clinical trial data.
DOI 10.64898/2026.02.20.706928