Carolina Segura-Morales

Mechanistic pathway modeling reveals how IL-10 generates pleiotropic immune responses

The paper develops a mathematical model of the IL-10 signaling pathway to explain its pleiotropic effects and suggests implications for IL-10-based therapies.

Exon inclusion signatures enable accurate estimation of splicing factor activity

The paper estimates splicing factor activity from exon inclusion changes, identifying cancer-related splicing programs and their association with patient survival and cancer hallmarks.

Targeting Pseudomonas aeruginosa Ventilator-associated pneumonia with a non-antibiotic and biolfilm-disrupting Live Biotherapeutic: Preclinical Safety and Efficacy study

This paper evaluates a non-antibiotic live biotherapeutic for treating Pseudomonas aeruginosa ventilator-associated pneumonia in preclinical models, showing reduced biofilm and bacterial load with improved safety and immunomodulatory effects.