John McEnany

Rapid evolution can select for fitness tradeoffs in fluctuating environments

This study develops a theory to predict how rapidly adapting populations select for fitness tradeoffs in fluctuating environments, showing that mutations with larger tradeoffs can be favored despite lower geometric mean fitness.

Dynamics of local B cell migration during affinity maturation in the human tonsil

This study shows that B cells in human tonsils migrate locally during affinity maturation at a consistent rate, contributing to diversity while balancing selection.

piRNAs of Caenorhabditis elegans broadly silence nonself sequences through functionally random targeting

The paper shows C. elegans piRNAs functionally target sequence space randomly, enabling broad silencing of nonself sequences.