NeurosciencebioRxivPreprint
Remodeling of purinergic signaling in the paraventricular hypothalamus promotes hyperphagic obesity and insulin resistance
Yu Liu, Anastasiia Bondarenko, Haiyang Zhang…·Ilya A. Vinnikov
This study shows that high-fat diet induces purinergic signaling in the hypothalamus, leading to obesity and insulin resistance, and that targeting P2Y12 can reverse these effects.
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