Pengwei Luan

An axonal brake on striatal dopamine output by cholinergic interneurons

This study shows that cholinergic interneurons in the striatum use nicotinic receptors to limit dopamine release by depressing axonal depolarization and calcium summation.

Remodeling of purinergic signaling in the paraventricular hypothalamus promotes hyperphagic obesity and insulin resistance

This study shows that high-fat diet induces purinergic signaling in the hypothalamus, leading to obesity and insulin resistance, and that targeting P2Y12 can reverse these effects.

Spatiotemporally selective ATP events from astrocytes encode injury information and guide sustained microglial response

The paper identifies Inflares, spatiotemporally selective ATP events from astrocytes, which encode injury information and guide microglial response, showing their role in both injury amplification and therapeutic reversal.