Clonal Evolution of Pediatric Acute Myeloid Leukemia and Its Contribution to Disease Relapse
Masayuki Umeda, Pandurang S. Kolekar, Anna L. W. Huskey, Shruthi Suryaprakash, Jing Ma, Hanxia Li, Tamara Westover, Michael Patrick Walsh, Guangchun Song, Yanling Liu, Quang Tran, Vidya Balagopal, Lu Wang, Samuel L. Brady, Stanley B Pounds, , Jeffery M. Klco
This study analyzes genetic changes in pediatric AML relapse using whole-genome sequencing and finds that relapse is driven by the selection of pre-existing clones rather than new mutations.
medRxiv · Nov 4, 2025 · PreprintGenetic & Genomic Medicine