Lu Wang

This study maps how 269 human transcription factors recognize DNA sequences on nucleosomes, revealing a second regulatory code in chromatin that influences gene regulation.

The paper analyzes somatic NMDe variants in oncogenes and dual-function genes across cancer cohorts, identifying two distinct patterns with different functional consequences.

This study analyzes genetic changes in pediatric AML relapse using whole-genome sequencing and finds that relapse is driven by the selection of pre-existing clones rather than new mutations.

This study presents cryo-EM structures of Mor-TAC and C-TAC complexes, revealing a tetrameric binding mode and interactions with RNAP, elucidating the transcription activation mechanism of phage Mor/C family activators.

The paper identifies Cramp1 as an evolutionarily conserved factor that suppresses transposon mobilization during somatic development by initiating H1 transcription and promoting H3K36me2-established heterochromatin.

The paper shows that Gypsy retrotransposon activation during Drosophila metamorphosis primes innate immunity, enhancing viral clearance in adult flies.

The paper identifies de novo mutations affecting post-transcriptional regulation that contribute to four neuropsychiatric disorders.

The paper identifies a lack of airway interferon activation as a marker of severe infant RSV infection and shows that blocking IFN signaling increases viral infection in vitro.

This study analyzes dingo genomes to identify genomic regions under selection during domestication and feralization, finding reversible selection in genes related to neurodevelopment, metabolism, and reproduction.