Bias toward long gene misregulation in synaptic disorders can be an artefact of amplification-based methods
Ayush T. Raman, Amy E. Pohodich, Ying‐Wooi Wan, Hari Krishna Yalamanchili, William E. Lowry, Huda Yahya Zoghbi, Zhandong Liu
The paper shows that apparent length-dependent gene misregulation in synaptic disorders is an artifact of amplification-based methods, not intrinsic to Mecp2 disruption.
Nature Communications · Aug 7, 2018Peer-reviewedNeuroscience