Ying‐Wooi Wan

Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model

The paper investigates how exercise affects Alzheimer's disease in mice by analyzing gene expression and chromatin changes, finding that growth factor signaling pathways are key to exercise's benefits.

Differential effects of MATR3 variants on its cryptic splicing repression function

This study investigates how MATR3 variants affect cryptic splicing repression, showing that some variants reduce protein solubility and impair RNA binding and splicing regulation.

CoRegNet: Unraveling Gene Co-regulation Networks from Public RNA-Seq Repositories Using a Beta-Binomial Statistical Model

CoRegNet constructs gene co-regulation networks from public RNA-Seq data using a beta-binomial model, outperforming existing methods and identifying non-linear and Simpson's paradox gene pairs.

MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function

This study identifies Gdf11 as a MeCP2-regulated gene critical for neurological function, showing that altering its dosage affects behavior and longevity in mouse models.

Latent factor in Brain RNA-seq studies reflects cell type and clinical heterogeneity

The paper identifies a latent factor in brain RNA-seq data that reflects cell type and clinical heterogeneity, improving the identification of biological pathways and biomarkers.

Most High Throughput Expression Data Sets are Underpowered

The paper argues that high-throughput expression datasets are underpowered due to insufficient biological replicates and recommends at least six per condition to improve reliability.

MECP2pedia: A Comprehensive Transcriptome Portal for MECP2 Disease Research

The paper aggregates and analyzes MeCP2 transcriptome data to identify a core set of perturbed genes and provides insights into MeCP2 function through a web portal.

Modulating glial genes involved in synaptic function mitigates pathogenesis and behavioral deficits in a Drosophila model of Huntington's Disease

The paper shows that reducing glial genes involved in synaptic function reduces disease pathology and behavioral issues in a Drosophila Huntington's Disease model.

Loss of Dnmt3a dependent methylation in inhibitory neurons impairs neural function through a mechanism that impacts Rett syndrome

This study shows that loss of Dnmt3a or MeCP2 in inhibitory neurons leads to distinct but overlapping neurological and molecular effects, with mCH playing a key role in Rett Syndrome pathogenesis.

Functional dissection of Alzheimer’s disease brain gene expression signatures in humans and mouse models

The paper identifies gene expression signatures in human and mouse brains linked to Alzheimer's disease and finds species-specific and shared patterns across neurodegenerative models.

Bias toward long gene misregulation in synaptic disorders can be an artefact of amplification-based methods

The paper shows that apparent length-dependent gene misregulation in synaptic disorders is an artifact of amplification-based methods, not intrinsic to Mecp2 disruption.