Hari Krishna Yalamanchili

This study identifies a shared cellular origin for supraclavicular brown adipocytes and beige adipocytes in inguinal white adipose tissue through lineage tracing.

This study shows that reducing ACSBG1 in astrocytes reduces inflammation and α-Synuclein pathology in a Parkinson's disease mouse model.

This study identifies big tau, a splice isoform of tau, as more abundant in brain regions resistant to Alzheimer's pathology and shows its protective properties in human patients.

The paper quantifies histone modifications and DNA methylation in mouse BAT under different cold conditions, revealing epigenetic changes linked to thermogenic response.

This study investigates how MATR3 variants affect cryptic splicing repression, showing that some variants reduce protein solubility and impair RNA binding and splicing regulation.

This study identifies SF3B1-dependent alternative splicing as essential for endometrial homeostasis and pregnancy, showing its role in decidualization and embryo implantation.

PolyAMiner-Bulk identifies and decodes alternative polyadenylation dynamics from bulk RNA-seq data, revealing novel APA changes in disease contexts and Alzheimer's Disease.

The paper aggregates and analyzes MeCP2 transcriptome data to identify a core set of perturbed genes and provides insights into MeCP2 function through a web portal.

The paper analyzes transcriptome and proteome changes in a Drosophila tauopathy model, identifying age- and Tau-induced gene expression differences and their cross-species implications.

The paper shows that partial loss of CFIm25, a protein regulated by NUDT21, causes learning deficits and molecular changes in neurons.

This study shows that Tau disrupts the spliceosome, leading to cryptic RNA splicing and neurodegeneration in Alzheimer’s disease.

The paper shows that apparent length-dependent gene misregulation in synaptic disorders is an artifact of amplification-based methods, not intrinsic to Mecp2 disruption.