NeuroscienceACS OmegaPeer-reviewed
Chemical targeting of the ATXN1 aa99-163 interaction site suppresses polyQ-expanded protein dimerization
Ioannis Gkekas, Katerina Pliatsika, Stelios Mylonas…·Spyros Petrakis
The paper identifies an interaction site between ATXN1 and MED15 and shows that targeting this site with a chemical compound reduces polyQ-expanded protein dimerization in SCA1.
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