Chemical targeting of the ATXN1 aa99-163 interaction site suppresses polyQ-expanded protein dimerization
Ioannis Gkekas, Katerina Pliatsika, Stelios Mylonas, Sotirios Katsamakas, Απόστολος Αξενόπουλος, Simona Kostova, Erich E. Wanker, Dimitra Hadjipavlou‐Litina, Konstantinos Xanthopoulos, Petros Daras, Spyros Petrakis
The paper identifies an interaction site between ATXN1 and MED15 and shows that targeting this site with a chemical compound reduces polyQ-expanded protein dimerization in SCA1.
ACS Omega · Jun 17, 2025Peer-reviewedNeuroscience