Deactivation of ligand-receptor interactions enhancing lymphocyte infiltration drives melanoma resistance to Immune Checkpoint Blockade
Sahil Sahni, Binbin Wang, Di Wu, Saugato Rahman Dhruba, Matthew R. Nagy, Sushant Patkar, Ingrid Ferreira, Chi‐Ping Day, Kun Wang, Eytan Ruppin
The paper identifies resistance-deactivated interactions (RDIs) as predictive biomarkers for ICB response in melanoma by analyzing transcriptomics data from multiple cohorts.
Nature Communications · Oct 14, 2024Peer-reviewedBioinformatics