Binbin Wang

This paper introduces LogiCAR designer, a computational method using single-cell transcriptomics to identify logic-gated antigen combinations for CAR therapy, showing improved efficacy and safety compared to existing approaches.

IMMClock predicts immune age of T cells and NK cells using gene expression, showing immune aging is more linked to cellular aging than differentiation and is accelerated in diseases.

The paper identifies resistance-deactivated interactions (RDIs) as predictive biomarkers for ICB response in melanoma by analyzing transcriptomics data from multiple cohorts.

This study identifies a decoupling signature that reduces the correlation between cytotoxic and exhausted T cell activities, improving the prediction of immunotherapy response in melanoma.

TISCH provides an interactive web resource for visualizing single-cell transcriptomic data of the tumor microenvironment across multiple cancer types.

TRUST detects TCR CDR3 regions in solid-tissue RNA-seq data with high sensitivity, even at low sequencing depth, and is applicable to large tumor cohorts.