Sahil Sahni

This study identifies ABCA1 as a cholesterol efflux protein that enhances anti-cancer functions of myeloid cells, with clinical relevance in breast tumors.

This paper develops DECODEM to predict chemotherapy response by integrating deconvolved expression patterns of immune, stromal, and tumor cells in breast cancer, finding that cell-type-specific expression is predictive of response.

IMMClock predicts immune age of T cells and NK cells using gene expression, showing immune aging is more linked to cellular aging than differentiation and is accelerated in diseases.

The paper identifies resistance-deactivated interactions (RDIs) as predictive biomarkers for ICB response in melanoma by analyzing transcriptomics data from multiple cohorts.