Michael P. Macoritto

The paper identifies treatment response-associated cell subpopulations in autoimmune diseases by integrating single-cell and bulk data from IBD and PsO patients, revealing key pathways and cell types involved in response or non-response.

This study identifies IL-32β as a ligand that primes human macrophages for M1-like inflammatory responses via a Myddosome-dependent pathway and shows elevated IL-32 in severe COVID-19.

A genome-wide CRISPR screen and genetic analysis identify TNRC18 as a novel regulator of IL-1β production and a risk factor for inflammatory diseases.