Cell BiologybioRxivPreprint
Inhibition of the neurodevelopmental disorder-associated 16p11.2 gene QPRT leads to altered cell type distribution in human stem cell-derived cerebral organoids
Julia Schwarzpaul, Clara M. Droell, Afsheen Kumar…·Denise Haslinger
This study inhibits QPRT in human stem cell-derived cerebral organoids, revealing altered cell type distribution and metabolic stress linked to neurodevelopmental disorders.