Dafu Chen

Melittin-induced membrane disruption in hepatocellular carcinoma involves mtROS/GSDME-mediated pyroptosis

This study shows melittin induces pyroptosis in HCC cells via mtROS and GSDME, challenging its traditional view as a membrane-lytic peptide.

Melittin intervention induces lncRNA response, mitochondrial dysfunction, and cell proliferation in murine cervical cancer cells

This study identifies melittin-responsive lncRNAs and their associations with mitochondrial dysfunction and reduced cell proliferation in murine cervical cancer cells.

The effect of melittin intervention on murine cervical cancer cells: An in-depth proteomics investigation

This study investigates melittin's effects on U14 cervical cancer cells using proteomics, showing inhibition of migration, invasion, and promotion of cell death with significant changes in oxidative stress and mitochondrial pathways.

Deciphering the Effect of Melittin on Murine Cervical Cancer Cells Based on Transcriptomic Investigation

This study investigates melittin's effects on murine cervical cancer cells, showing it inhibits viability, suppresses migration, induces apoptosis, and disrupts metabolic and angiogenic pathways.

Transcriptomic datasets of melittin- and un-treated murine cervical carcinoma U14 cells

The paper generates RNA-seq datasets of melittin-treated and untreated murine cervical carcinoma U14 cells, identifying 254 differentially expressed genes and providing a transcriptomic resource for studying melittin's anti-cancer effects.

Comprehensive transcriptome data of melittin- and un-treated murine hepatoma Hepa 1-6 cells

This paper presents transcriptomic data from melittin-treated and untreated murine hepatoma cells to study melittin's effects on gene expression.

CircRNAs and their regulatory networks associated with the antioxidant enzymes and immune responses of Asian honey bee larvae to fungal infection

Effect of Ascosphaera apis infestation on the activities of four antioxidant enzymes in Asian honey bee larval guts

This study investigates how A. apis infection affects antioxidant enzyme activities in Asian honey bee larvae, finding reduced SOD and CAT, increased PPO, and induced GST.

ame-miR-34 modulates the larval body weight and immune response of Apis mellifera workers to Ascosphara apis invasion

This study investigates the role of ame-miR-34 in modulating larval body weight and immune response of honeybees to Ascosphara apis infection through overexpression and knockdown experiments.

Differential expression patterns and potential regulatory function of piRNAs in western honey bee larval response to Ascosphaera apis infestation

This study identifies differentially expressed piRNAs in western honey bee larvae infected with Ascosphaera apis and explores their potential regulatory roles in immune and metabolic responses.

First identification and investigation of piRNAs in the larval guts of Asian honey bee, Apis cerana

The paper identifies and investigates piRNAs in the larval guts of Asian honey bee, revealing their expression patterns and regulatory roles in development.

Comparative transcriptome investigation of Nosema ceranae infecting eastern honeybee workers

This study compares the transcriptomes of Nosema ceranae infected and uninfected eastern honeybee workers to identify differentially expressed genes and their functional roles in infection.

Impact of Nosema ceranae invasion on sucrose solution consumption, midgut epithelial cell structure, and lifespan of Apis cerana cerana workers

This study investigates the effects of Nosema ceranae infection on sucrose consumption, midgut cell structure, and lifespan in Apis cerana cerana workers, finding increased sucrose consumption, structural damage, and reduced lifespan in infected individuals.

Nanopore-based genome-wide DNA methylation sequencing data of Nosema ceranae-inoculated and un-inoculated eastern honeybee workers' midguts

The paper reports Nanopore-based DNA methylation sequencing data from honeybee midguts inoculated with Nosema ceranae and controls, identifying 5mC and 6mA methylation sites involved in host response to infection.

Deciphering the mechanism underlying circRNA-mediated immune responses of western honeybees to Nosema ceranae infection

This paper identifies differentially expressed circRNAs in western honeybees infected with Nosema ceranae and links them to immune-related pathways and miRNA-mRNA interactions.

Comprehensive transcriptome data of normal and Ascosphaera apis-infected western honeybee larval guts

The paper provides transcriptome data from normal and Ascosphaera apis-infected western honeybee larval guts, facilitating studies on host-pathogen interactions and non-coding RNA regulation.

Strand-specific cDNA library-based RNA sequencing dataset of un-infected and Ascosphaera apis-infected larval guts of Apis cerana cerana

The paper presents an RNA sequencing dataset comparing gene expression in un-infected and Ascosphaera apis-infected larval guts of Apis cerana cerana to study host-pathogen interactions.

Pacific Biosciences long reads-based genome sequencing data from a widespread bee fungal parasite, Nosema ceranae

The paper reports the genome sequencing of Nosema ceranae using PacBio SMRT technology, providing insights into its molecular biology and potential gene functions.

Genome-wide bisulfite sequencing data of normal and Ascosphaera apis-infected larval guts of eastern honeybee

The paper reports genome-wide bisulfite sequencing data from normal and Ascosphaera apis-infected larval guts of eastern honeybee to study DNA methylation changes during infection.

Whole genome bisulfite sequencing dataset of mycelium and spore of chalkbrood disease pathogen Ascosphaera apis

The paper provides whole genome bisulfite sequencing data for mycelium and spore of Ascosphaera apis to identify 5mC methylation sites and compare methylomes between life stages.

Nanopore-based long-read transcriptome data of Nosema ceranae-infected and un-infected western honeybee workers' midguts

The paper uses Nanopore long-read sequencing to analyze transcriptomes of Nosema ceranae-infected and un-infected honeybee midguts, revealing differences in transcript length and quality.

A full-length transcriptome dataset of normal and Nosema ceranae-challenged midgut tissues of eastern honeybee workers

The paper presents a full-length transcriptome dataset of normal and Nosema ceranae-challenged midgut tissues of eastern honeybee workers using Nanopore long-read sequencing.

MeRIP-seq and RNA-seq data of mycelium and spore of Ascosphaera apis, a widespread bee fungal pathogen

The paper presents MeRIP-seq and RNA-seq data from mycelium and spores of Ascosphaera apis to study m6A modification patterns and their relationship with transcript levels.

Whole transcriptome data of uninfected and Nosema ceranae-infected midguts of eastern honeybee workers

The paper presents RNA-seq data from uninfected and Nosema ceranae-infected midguts of eastern honeybees to study host-parasite interactions and gene expression changes.

Nanopore long-read transcriptome data of fungal pathogen of chalkbrood disease, Ascosphaera apis

The paper presents long-read transcriptome data of Ascosphaera apis, a fungal pathogen, to improve genome and transcriptome annotations and study alternative splicing and polyadenylation.

Long-read transcriptome data of bee fungal parasite, Nosema ceranae

The paper generates long-read transcriptome data for Nosema ceranae using Nanopore sequencing to improve its transcriptome quality.

Reconstruction and functional annotation of Ascosphaera apis full-length transcriptome via PacBio single-molecule long-read sequencing

This paper generates the first full-length transcriptome of Ascosphaera apis using PacBio sequencing, identifies novel transcripts and lncRNAs, and validates isoform expression.

Comparative identification of microRNAs in Apis cerana cerana workers'midguts responding to Nosema ceranae invasion

This study identifies miRNAs in A. cerana cerana workers' midguts responding to N. ceranae infection, revealing differentially expressed miRNAs and their potential roles in immune responses.

Genome-wide identification of long non-coding RNAs and their regulatory networks involved in Apis mellifera ligustica response to Nosema ceranae infection

The paper identifies lncRNAs and their regulatory networks in honeybees responding to Nosema ceranae infection using RNA sequencing and bioinformatics analysis.

Systematic identification of circular RNAs and corresponding regulatory networks unveil their potential roles in the midgut of Apis cerana cerana workers

This study identifies circRNAs and their regulatory networks in the midgut of eastern honeybees, revealing their potential roles in midgut development through ceRNA mechanisms.