Author

Michael J. Manefield

UNSW SydneyORCID 0000-0002-1880-0888Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:metagenomics· 1

Frequent Co-Authors

Alessandro T. CaputoiD· 1 shared Colin ScottiD· 1 shared Frank E. LöffleriD· 1 shared G. S. LiuiD· 1 shared H Z WangiD· 1 shared Huijuan JiniD· 1 shared Jingjing WangiD· 1 shared Jun YaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperSynthetic Biology

Alessandro T. CaputoORCID

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2 papers

Recent·Most cited

Cobamide-Dependent Dichloromethane Fermentation by Dehalobacter Reveals a Hidden Acetogenic Route for Organohalide Biotransformation

Huijuan Jin, Xiuying Li, Xin Wang, H Z Wang, Jingjing Wang, Ke Shi, G. S. Liu, Tongyue Zhou, Siqi Huang, Michael J. Manefield, Frank E. Löffler, Jun Yan, Yi Yang

The paper identifies a cobamide-dependent fermentation pathway in Dehalobacter that converts dichloromethane to acetate and formate, revealing an acetogenic lifestyle previously unknown in this genus.

bioRxiv · May 27, 2026 · PreprintMicrobiology

Selective Hydrolytic Defluorination of Branched Perfluorooctanoic Acid Isomers by a Haloacid Dehalogenase

Miao Hu, Shefali Bhardwaj, Sophia Newton, Alessandro T. Caputo, Michael J. Manefield, Colin Scott

This paper demonstrates that a haloacid dehalogenase selectively defluorinates branched PFOA isomers, expanding the known catalytic scope of this enzyme family.

bioRxiv · Apr 20, 2026 · PreprintSynthetic Biology