Colin Stephen Scott

This paper demonstrates that a haloacid dehalogenase selectively defluorinates branched PFOA isomers, expanding the known catalytic scope of this enzyme family.

The paper develops a whole-cell biosensor for ethylene oxide and ethylene using genetic parts from Mycobacterium, achieving detection limits of 0.2 μM for ethylene oxide and detecting ethylene from banana fruit.

The paper develops a cyanamide-inducible system for genome engineering in yeast, enabling selectable marker recycling and promoter characterization.

The paper develops a bacterial toxin-antitoxin system to manipulate and visualize tandem gene repeat copy numbers in yeast.

The paper investigates how active site mutations in FDOR enzymes affect stereoselectivity and reveals that a Tyr-Met mutation reverses stereoselectivity and alters hydrogenation mode.

This paper engineers methanol assimilation pathways in yeast and identifies a latent methylotrophic metabolism, improving growth and metabolite labeling through genetic modifications.

The paper describes engineered enzymes that retain and regenerate cofactors, enabling continuous-flow biocatalysis.

The paper revises the biosynthetic pathway for the cofactor F420 in bacteria by identifying the correct substrate for guanylyltransferases and elucidating the role of the C-terminal domain of FbiB.