Prateek D. Bansal

This study identifies sequence constraints that predispose Class D GPCRs to an atypical activation mechanism involving TM7 displacement and TM6 inward movement.

This study uses MD simulations to show that Class B1 GPCRs share a common activation mechanism involving an intermediate state with outward movement of helix 6, but exhibit clade-specific residue-level differences.

The paper investigates cholesterol translocation mechanisms in the Smoothened receptor using simulations and experiments, showing that outer leaflet translocation has a lower energy barrier.

This study uses simulations to show cyclopamine acts as an agonist when bound to the CRD of Smoothened and as an antagonist when bound to the TMD, with mixed effects when bound to both sites.