Molecular BiologybioRxivPreprint
Phase separation of ecDNA aggregates establishes in-trans contact domains boosting selective MYC regulatory interactions
Mattia Conte, Tommaso Matteuzzi, Andrea Esposito…·Mario Nicodemi
The paper investigates how ecDNA clusters form through phase separation, creating regulatory contacts that boost MYC expression, and shows how JQ1 disrupts this process.