Francesca Vercellone

The paper uses polymer physics models and simulations to show how chimeric proteins cause aberrant chromatin looping, and proposes strategies to inhibit this process.

The paper uses polymer physics models to simulate and analyze the 3D structure of the LTN1 gene region, comparing results with Hi-C data to predict structural features for microscopy experiments.

The paper investigates how ecDNA clusters form through phase separation, creating regulatory contacts that boost MYC expression, and shows how JQ1 disrupts this process.