This study uses single-cell and spatial transcriptomics to analyze stomach evolution across 23 vertebrate species, identifying cell-type adaptations and genes linked to dietary changes and rumination.

bioRxiv · Mar 11, 2026 · PreprintEvolutionary Biology

Telomere-to-telomere genome assembly of a male goat reveals novel variants associated with cashmere traits

Hui Chen Wu, Ling-Yun Luo, Yahui Zhang, Chong-Yan Zhang, Jia-Hui Huang, Dong-Xin Mo, Li-Ming Zhao, Zhixin Wang, Yichuan Wang, EEr Hehua, Wen-Lin Bai, Di Han, Xingtang Dou, Yanling Ren, Renqing Dingkao, , Meng-Hua Li

The paper presents a telomere-to-telomere goat genome assembly, identifies structural variants and genes associated with domestication and cashmere traits, and expands the reference genome with previously unresolved regions.

Nature Communications · Nov 20, 2024Peer-reviewedGenomics

Telomere-to-telomere sheep genome assembly reveals new variants associated with wool fineness trait

Ling-Yun Luo, Hui Wu, Liming Zhao, Yahui Zhang, Jia-Hui Huang, Qiuyue Liu, Hai-Tao Wang, Dong-Xin Mo, He-Hua EEr, Lianquan Zhang, Hailiang Chen, Shangang Jia, Weimin Wang, Meng-Hua Li

The paper presents a complete telomere-to-telomere sheep genome assembly that improves variant detection and identifies new genes and variants associated with wool fineness.

bioRxiv · Jul 21, 2024 · PreprintGenomics

A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

Ze Yan, Ji Hyun Yang, Wen-Tian Wei, Mingliang Zhou, Dong-Xin Mo, Xing Wan, Rui Ma, Mei-Ming Wu, Jia-Hui Huang, Ya-Jing Liu, Feng‐Hua Lv, Meng-Hua Li

This study generates a time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues in sheep, identifying key genes and regulatory elements involved in hypoxia adaptation.

Nature Communications · May 10, 2024Peer-reviewedGenetics