Rui Ma

This study generates a time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues in sheep, identifying key genes and regulatory elements involved in hypoxia adaptation.

This study shows that KDM6A is required for Xist upregulation during X inactivation initiation in mouse ES cells, as its knockout impairs Xist RNA coating and leads to aberrant Xi gene expression.