Random in vitro Protein single-Loop Engineering (RiPLE) by mRNA display
Kilian Colas, Tongil Ko, Grégoire J.-B. Philippe, Hiroaki Suga
This paper introduces RiPLE, a method for discovering engineered protein binders, and shows it produces high-affinity, selective binders for ROR1 and GS.
bioRxiv · Sep 22, 2026 · PreprintBioengineering