The conserved DNMT1 dependent methylation regions in human cells are vulnerable to environmental rotenone.
Dana M. Freeman, Dan Wen Lou, Yanqiang Li, Suzanne N. Martos, Zhibin Wang
The paper investigates non-germline allele-specific DNA methylation (ASM) regions in humans, showing they are conserved and vulnerable to rotenone exposure, leading to gene expression changes and hypomethylation at neurological genes.
bioRxiv · Oct 9, 2019 · PreprintMolecular Biology