Yanqiang Li

This paper introduces a direct RNA sequencing workflow to profile tRNA abundance and modifications in mouse liver, identifying key modification sites and isotype-specific patterns.

ANCHOR improves variant calling and allele-specific expression analysis in single-cell long-read RNA-seq by integrating haplotype-aware methods and beta-binomial modeling.

The paper introduces MACMIC, a method to identify feature pairs with maximal colocalization and minimal correlation, revealing CTCF's dual role in regulating cell identity genes through epigenetic mechanisms.

The paper investigates non-germline allele-specific DNA methylation (ASM) regions in humans, showing they are conserved and vulnerable to rotenone exposure, leading to gene expression changes and hypomethylation at neurological genes.