Author

Dan Wen Lou

Johns Hopkins UniversityORCID 0000-0002-9269-4737Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adhithiya Charli· 1 shared Anumantha G. KanthasamyiD· 1 shared Arthi KanthasamyiD· 1 shared Dana M. FreemaniD· 1 shared Dehui Kong· 1 shared Huajun JiniD· 1 shared Minhong HuangiD· 1 shared Suzanne N. MartosiD· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperNeuroscience

Adhithiya Charli

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Mitochondrial Dysfunction Induces Epigenetic Dysregulation by H3K27 Hyperacetylation to Perturb Active Enhancers in Parkinson’s Disease Models

Minhong Huang, Dan Wen Lou, Adhithiya Charli, Dehui Kong, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Zhibin Wang, Anumantha G. Kanthasamy

This study shows that mitochondrial dysfunction in Parkinson’s disease models leads to H3K27 hyperacetylation, disrupting active enhancers and epigenetic regulation.

bioRxiv · Oct 17, 2019 · PreprintNeuroscience

The conserved DNMT1 dependent methylation regions in human cells are vulnerable to environmental rotenone.

Dana M. Freeman, Dan Wen Lou, Yanqiang Li, Suzanne N. Martos, Zhibin Wang

The paper investigates non-germline allele-specific DNA methylation (ASM) regions in humans, showing they are conserved and vulnerable to rotenone exposure, leading to gene expression changes and hypomethylation at neurological genes.

bioRxiv · Oct 9, 2019 · PreprintMolecular Biology